Abstract Numerous novel and effective therapeutic agents and clinical trials addressing castration-resistant prostate cancer (CRPC) Pelt were reported during the 2023 American Society of Clinical Oncology-Genitourinary (ASCO-GU) Cancers Symposium.Notably, radionuclide drug conjugates (RDC), specifically 177Lu/111In-J591 and 225Ac-J591, exhibited en
Investigation of the Binding Affinity of a Broad Array of l-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin
Series of multivalent α-l-fucoside containing glycoclusters and variously decorated l-fucosides were synthesized to find potential inhibitors of fucose-specific lectins and study the structure-binding affinity relationships.Tri- and Starters tetravalent fucoclusters were built using copper-mediated azide-alkyne click chemistry.Series of fucosi
PROTAC technology for prostate cancer treatment
Prostate cancer (PrCa) is the most prevalent urogenital cancer affecting men.PrCa is marked by uncontrolled cellular growth that leads to abnormal enlargement of the prostate gland.The metastatic spread of PrCa is the primary cause of mortality, causing cancer cell dissemination to distant sites, such as bones, the pelvis, and various visceral orga
Variability of COVID-19 mortality in Honduras: influence of sociodemographic factors
Abstract Background In Central America, Honduras experienced a significant increase in SARS-CoV-2 infections between March 11, 2020, and January 26, 2022.Although limited research has been conducted on the impact of the COVID-19 pandemic on populations in Central American countries, this study seeks to contribute to the existing body of knowledge i